Chronic stress has a powerful influence on the way our genes express themselves—this is the field of Epigenetics, where the environment and our internal experiences can literally shape how genes are turned “on” or “off.” When we experience stress over a long period, it triggers cellular signalling patterns that alter the chemical markers on DNA and histones, which regulate gene activity. In essence, chronic stress doesn’t change the DNA code itself—it changes how the code is read and activated. 

Over time, these epigenetic shifts can amplify the body’s inflammatory responses, reduce immune function, and disrupt hormonal balance. Genes related to growth, repair, and neuroplasticity may be downregulated, while those related to inflammation, vigilance, and survival stay active. This keeps the body locked in a defensive mode, prioritizing short-term survival over long-term health and healing.

Interestingly, these stress-related epigenetic marks can persist long after the stressful events are over, influencing how the nervous system and body respond to future challenges. They can even be passed down through generations, predisposing offspring to heightened stress sensitivity.

The encouraging part is that these patterns are not permanent. Practices that promote safety, regulation, and coherence—such as meditation, breath work, supportive relationships, and therapies that calm the nervous system, can help reverse or reprogram stress-based epigenetic expressions. In this way, the way we live, feel, and connect can rewrite the story our genes tell about our health and potential.